ABSTRACT: Anxiety, mood, and sleep disturbances are frequent disturbances that have been treated with natural derivatives since ancient times. The purpose of this work is the evaluation of the impact of a food supplement containing: Pueraria lobata, Crocus sativus, Griffonia simplicifolia, L-tryptophan, Magnesium, and Relaxmel, on the emotional state of patients with anxiety and mood disorders. The study recruited 49 patients aged between 19 and 76 years and 30 controls aged between 19 and 67 years. Affective status was assessed by State-Trait Anxiety Inventory (STAI X1/X2) and Beck Depression Inventory (BDI). STAI X1 showed an average pre/post-treatment value of 68.93 +2.97 and 51.27 +8.07 (p <0.001), STAI X2 an average pre/post-treatment value of 70.07 +3.09 and 51.04 +6.93 (p <0.001) and BDI an average value of 20.12 +4.33 and 10.75 +3.15 (p <0.001). The comparison with control subjects obtained a significant interaction between group and time factors (p<0.0001 for the STAI X1, STAI X2, and BDI), showing that the values of treated subjects decreased significantly for the control group. Treatment tolerability was high with an average value of 9.67 +0.56. Dietary supplementation has proven effective in the treatment of anxiety and mood disorders in a relatively short period (60 days) with excellent tolerability.
